Winning insights: Prize awarded to researchers investigating a new potential drug target for Chagas disease
Our huge congratulations go to Dr Daniele Chame (above), post-doctoral research associate from the Federal University of Minas Gerais (UFMG), Brazil, and Carlos Estevez, a masters’ student at UFMG, co-recipients of the 2019 Zigman Brener award at the XXXV Annual Meeting of the Brazilian Society for Protozoology (SBPz). Daniele and Carlos, two of our NTD Network early career researchers from Professor Santuza Teixeira’s team at UFMG, Belo Horizonte, presented their findings as a poster in the Translational Biology session during the meeting, held this year in Caxambu, Brazil, 4th-6th November. Daniele accepted the prize alone, as Carlos was at our “Workshop in Drug Discovery” training and industry symposium, held in Mendoza, Argentina, 2nd-4th November. … Continue reading
This November, our student training workshop “New anti-leishmanial leads from natural sources”, hosted at the International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, brought together an international team of staff and 30 early career researchers from south Asia and across the Middle East.
For Dr Paul Denny and myself, the visit included a meeting with Dr Bahram Khoso and his clinical team at Jinnah hospital, Karachi; here, the human reasons behind our pre-clinical research became clear, and very real. Before us stood four children, siblings; each face disfigured by cutaneous leishmaniasis.
The latest NTD Network training workshop, ‘New Anti-leishmanial leads from Natural Sources: Concepts and Approaches’, went live today!
This workshop provides practical training for PhD students, post-docs and faculty members in basic concepts and modern applications to find new anti-leishmanials using natural sources, and is held at the International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan.
Pharmaceuticals industry representatives, NTD Network members and associated colleagues are now on their way to Mendoza, Argentina, to deliver an early career researcher (ECR) training workshop in medicinal chemistry skills, held 2nd-4th November, 2019. This three-day training, “Workshop in techniques and technologies in drug discovery”, will provide ECRs from neglected disease-endemic countries throughout South America with skills in medicinal chemistry and the drug discovery process. The final session of the workshop is an open symposium of drug discovery case studies, delivered by representatives from Novartis, GSK and DNDi. This symposium is free to attend: industry symposium flyer.
The last four months have ‘flown by’ for Arielly Barreto, from Professor Bartira Rossi Bergmann’s lab the Federal University of Rio de Janeiro (UFRJ), in Brazil. Her secondment to Durham’s Department of Chemistry, supported by an NTD Network research bursary, has enabled her to progress her PhD studies – although not every learning has been directly about her work. Arielly (front left), with supervisor Professor Patrick Steel (front right) and other lab colleagues, also shared a lab outing to Whitby (featured in Bram Stoker’s ‘Dracula), and Scarborough – for croquet; a team game, involving navigating a course of narrow hoops, using wooden balls and a mallet, (and featured in Lewis Carroll’s tale, ‘Alice in Wonderland’). No surprise then, that this, Arielly’s first visit to the UK has been “… like walking into a story book!”.
Seeing further: A Brazil-UK collaboration to shine light on the mysteries of parasite cell membranes
“If I have seen further, it has been through standing on the shoulders of giants” (John of Salisbury, 1159).
NTD Network partners and colleagues from Durham, UK and universities from across Sao Paulo state in Brazil gathered this week at Durham University to launch an inter-institutional sister collaboration, investigating transmembrane proteins from neglected tropical diseases (NTDs) and other infectious agents. The FAPESP-SPRINT initiative project is a joint venture between the UK’s Biotechnology and Biological Sciences Research Council (BBSRC) and Brazil’s Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP). Membrane proteins hold huge potential as drug targets, yet are poorly understood, this ‘invisibility’ due to the technical challenges of working with these often insoluble proteins. This collaboration, between Durham University, the University of São Paulo (USP) and the Brazilian Biosciences National Laboratory (LNBio), combines the cross-disciplinary expertise from all three institutions. The team plan to develop a suite of tools for characterising the membranes of living cells, equipping us to ‘see further’ in our search for new drug targets for Chagas disease, leishmaniasis and other NTDs.
Today the National Scientific and Technical Research Council (CONICET) in Argentina published an interview with Professor Claudio Pereira on the NTD Network and the role of our Network partners amongst its membership. The Network project is seeking novel drug targets towards solutions for two neglected tropical diseases, Chagas disease and leishmaniasis, alongside forging new industrial collaborations and training early career researchers in the specialist skills needed for this vital work.
Claudio, based at the Instituto de Investigaciones Medicas Alfredo Lanari in Buenos Aires (IDIM, CONICET-BA) is scoping the druggable potential of proteins involved cross-membrane transport of metabolites in Trypanosoma cruzi (causing Chagas disease). Read the interview on the work of Claudio and his team, here.
Our other partners are Professor Julia Cricco at the Institute of Molecular and Cellular Biology of Rosario (IBR, CONICET-UNR), investigating components of heme uptake and biosynthesis, and Professor Guillermo Labadie at the Rosario Institute of Chemistry (IQUIR, CONICET-UNR), investigating naturally-sourced compounds for their potential as novel anti-parasitic drugs.
Guilllermo is co-organising an upcoming Network training workshop in skills for drug discovery, at Mendoza City, Argentina, 2-4 November 2019; bursaries are available to support students to attend. Workshop information is available via our events page.
“Structure is the starting point for understanding any protein!”
Dr Amy Goundry is currently a post-doctoral research associate from the lab of Ana Paula Lima (Federal University of Rio de Janeiro). Amy’s career to date has focussed on one, puzzling protein. “Inhibitor of Serine Peptidase 2” (ISP2), is a protein found in Leishmania parasites, enabling them to infect their mammalian (including human) hosts. Serine peptidases are enzymes with key roles in health and disease, appearing in organisms everywhere from viruses and bacteria to humans – everywhere that is, except in Leishmania. Once a sandfly bite has introduced Leishmania parasites into the body of a mammal host, they must quickly infect white blood cells, and modify the behaviour of these cells, in order to survive. The parasites produce ISP2, which inactivates white blood cell serine peptidases and halts the immune response.
“…but after more than a decade of research, we still don’t know how ISP2 works!”
This puzzle has brought Amy to Durham University for a 5-week secondment with our structural biologists – Dr Ehmke Pohl and the crystallography team.