Category: Publications

Crystallising a new collaboration: Researchers reveal the structure of Leishmania donovani Rab5a protein

Congratulations to Network members Dr Ashish Arora (CSIR-CDRI, Lucknow, India) and Professor Ehmke Pohl (Durham University, UK) and their teams, on their first joint publication!  Ashish and Ehmke met at the Network’s first HUB meeting in India, May 2018, and subsequently began collaborating to solve the crystal structure of the Leishmania donovani RAB5a protein, which is essential for parasite survival in its human host.  Their work, funded via a NTD Network ‘Pump Priming’ allocation, establishes new links between their respective research institutions, and has supported the imitation of what Ashish and Ehmke intend as a long and fruitful partnership; one which could, in time, enable discovery of a new ‘druggable’ therapeutic target against visceral forms of leishmaniasis, a potentially lethal neglected tropical disease (NTD).

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In the spotlight: NTD Network research highlighted in new RSC Medicinal Chemistry themed collection

This May saw the launch of a new themed collection of articles from the Royal Society of Chemistry’s journal, RSC Medicinal Chemistry, bringing together scientific breakthroughs and incisive insights from global experts seeking new routes to therapeutic solutions for neglected tropical diseases (NTDs).  This themed collection, entitled “Neglected Tropical Diseases” and edited by NTD Network members Dr Charles Mowbray (DNDi), Professor Nahid Ali (IICB Kolkata) and Dr Steven Cobb (Durham University), currently includes 15 articles. Read their editorial introduction to this collection here.
Three of these papers are co-authored by our own Network researchers, although all of them highlight, by example, our vital need for cross-disciplinary, multi-institutional approaches and long-term collaborations in order to make new progress against the old challenge of NTDs, which together threaten the lives of over a billion people worldwide.  First of the reserch papers is a review co-authored by one of our NTD Network Fellows, Dr. Kalesh Karunakaran (Durham University, UK).

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