Using CRISPR to shed light on new solutions for two old, ‘invisible’ diseases

July, 2018; and as the cool of evening descends over Rio de Janeiro, 22 young researchers from South America and the UK gather, excited and a little nervous, to meet each other and their tutors for the next 5 days.  The teaching team of 9 international experts are here to provide training in use of CRISPR-Cas9 technology in trypanosomes (Tryps), the parasites that cause the neglected tropical diseases (NTDs) Chagas disease (American trypanosomiasis) and leishmaniasis.  The students’ excitement is justified; their new skills will transform their professional lives, and may also be life-changing for many of the ~0.5 billion people worldwide at risk from these infections.1-4 This ground-breaking training is also available in Kolkata, India, in March 2019.

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Tryps, drugs, (metabolism) and rock ‘n’ roll: An interview with Ariel Silber

“I always said there were two things I’d never do: 

parasites and metabolism!”

Professor Ariel Silber, from the University of São Paulo (USP), the NTD Network hub leader for South America, laughs as he recalls himself as an impetuous undergraduate.  Ariel is a specialist in trypanosomes (Tryps); single-celled parasites causing the neglected tropical diseases (NTDs) Chagas disease, leishmaniasis and sleeping sickness.  We are catching up over a coffee during his visit with Durham NTD Network members.

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