This page provides downloadable research publications from our partners across the NTD Network.

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)

William D. Brittain and Steven L. Cobb

Published July 12, 2021

Computational approaches for drug discovery against trypanosomatid caused diseases

Claudio A. Pereira), Melisa Sayé, Chantal Reigada, Ariel M. Silber, Guillermo R. Labadie, Mariana R. Miranda and Edward Valera-Vera

Published February 12, 2020

Crystal violet structural analogues identified by in silico drug repositioning present antiTrypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

Melisa Saye, Lucrecia Gauna, Edward Valera-Vera, Chantal Reigada, Mariana R. Miranda, Claudio A. PereiraI

Published January 21, 2020

Amino acid and polyamine membrane transporters in Trypanosoma cruzi: Biological function and evaluation as drug targets

Melisa Sayé, Chantal Reigada, Lucrecia Gauna, Edward A. Valera-Vera, Claudio A. Pereira*, Mariana R. Miranda.

Published November 15, 2019

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing

Chantal Reigada, Melisa Sayé, Otto Phanstiel IV, Edward Valera-Vera, Mariana R. Miranda and Claudio A. Pereira

Published November 8, 2019

Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi

Florencia Díaz-Viraqué, Sebastián Pita, Gonzalo Greif, Rita de Cassia Moreira de Souza, Gregorio Iraola and Carlos Robello

Published July 1, 2019

Mining for natural product antileishmanials in a fungal extract library

A. J. Mbekeani, R. S. Jones, M. Bassas Llorens, J. Elliot, C. Regnault, M. P. Barrett, J. Steele, B. Kebeded, S. K. Wrigley, L. Evans, P. W. Denny

Published June 11, 2019

Repurposing of terconazole as an anti Trypanosoma cruzi agent

Chantal Reigada, Melisa Saye, Edward Valera-Vera, Mariana R. Miranda, Claudio A. Pereira

Published June 1, 2019

Biology of the Trypanosoma cruzi Genome

Luisa Berná, Sebastián Pita, María Laura Chiribao, Adriana Parodi-Talice, Fernando Alvarez-Valin and Carlos Robello

Published May 23, 2019

The Tritryps Comparative Repeatome: Insights on Repetitive Element Evolution in Trypanosomatid Pathogens

Sebastián Pita, Florencia Díaz-Viraqué, Gregorio Iraola and Carlos Robello

Published February 1, 2019

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Cristiana T. Trinconi, Danilo C. Miguel, Ariel M. Silber, Christopher Brown, John G.M. Mina, Paul W. Denny, Norton Heise, Silvia R.B. Uliana

Published October 23, 2018

Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening

Paul W. Denny

Published October 16, 2018

Early Trypanosoma cruzi infection triggers mTORC1-mediated respiration increase and mitochondrial biogenesis in human primary cardiomyocytes

M. Gabriela Libisch, Paula Faral-Tello, Nisha J. Garg, Rafael Radi, Lucía Piacenza and Carlos Robello

Published August 16, 2018

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi

Luisa Berna, Matias Rodriguez, María Laura Chiribao, Adriana Parodi-Talice, Sebastian Pita, Gastón Rijo, Fernando Alvarez-Valin and Carlos Robello

Published April 3, 2018

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

Letícia Marchese, Janaina de Freitas Nascimento, Flávia Silva Damasceno, Frédéric Bringaud, Paul A. M. Michels and Ariel Mariano Silber

Published April 1, 2018

A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine

Emily G. Armitage , Amjed Q. I. Alqaisi, Joanna Godzien, Imanol Peña , Alison J. Mbekeani , Vanesa Alsonso-Herranz, Ángeles López-Gonzálvez, Julio Martín, Raquel Gabarro, Paul W. Denny, Michael P. Barrett and Coral Barbas

Published February 20, 2018

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Jennifer L. Norclife, John G. Mina, Emilio Alvarez, Juan Cantizani, Francisco de DiosAnton, Gonzalo Colmenarejo, Silva Gonzalez-Del Valle, Maria Marco, José M. Fiandor, Julio J. Martin, Patrick G. Steel & Paul W. Denny

Published March 2, 2018

Genetically validated drug targets in Leishmania: Current knowledge and future prospects

Nathaniel G. Jones, Carolina M. C. Catta-Preta, Ana Paula C. A. Lima and Jeremy C. Mottram

Published January 31, 2018

Microbial protein targets: towards understanding and intervention

Paul W. Denny

Published November 16, 2017