This page provides downloadable research publications from our partners across the NTD Network.

Mining for natural product antileishmanials in a fungal extract library

A. J. Mbekeani, R. S. Jones, M. Bassas Llorens, J. Elliot, C. Regnault, M. P. Barrett, J. Steele, B. Kebeded, S. K. Wrigley, L. Evans, P. W. Denny

Published June 11, 2019

Repurposing of terconazole as an anti Trypanosoma cruzi agent

Chantal Reigada, Melisa Saye, Edward Valera-Vera, Mariana R. Miranda, Claudio A. Pereira

Published June 1, 2019

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Cristiana T. Trinconi, Danilo C. Miguel, Ariel M. Silber, Christopher Brown, John G.M. Mina, Paul W. Denny, Norton Heise, Silvia R.B. Uliana

Published October 23, 2018

Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening

Paul W. Denny

Published October 16, 2018

Early Trypanosoma cruzi infection triggers mTORC1-mediated respiration increase and mitochondrial biogenesis in human primary cardiomyocytes

M. Gabriela Libisch, Paula Faral-Tello, Nisha J. Garg, Rafael Radi, Lucía Piacenza and Carlos Robello

Published August 16, 2018

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi

Luisa Berna, Matias Rodriguez, María Laura Chiribao, Adriana Parodi-Talice, Sebastian Pita, Gastón Rijo, Fernando Alvarez-Valin and Carlos Robello

Published April 3, 2018

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

Letícia Marchese, Janaina de Freitas Nascimento, Flávia Silva Damasceno, Frédéric Bringaud, Paul A. M. Michels and Ariel Mariano Silber

Published April 1, 2018

A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine

Emily G. Armitage , Amjed Q. I. Alqaisi, Joanna Godzien, Imanol Peña , Alison J. Mbekeani , Vanesa Alsonso-Herranz, Ángeles López-Gonzálvez, Julio Martín, Raquel Gabarro, Paul W. Denny, Michael P. Barrett and Coral Barbas

Published February 20, 2018

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Jennifer L. Norclife, John G. Mina, Emilio Alvarez, Juan Cantizani, Francisco de DiosAnton, Gonzalo Colmenarejo, Silva Gonzalez-Del Valle, Maria Marco, José M. Fiandor, Julio J. Martin, Patrick G. Steel & Paul W. Denny

Published March 2, 2018

Genetically validated drug targets in Leishmania: Current knowledge and future prospects

Nathaniel G. Jones, Carolina M. C. Catta-Preta, Ana Paula C. A. Lima and Jeremy C. Mottram

Published January 31, 2018

Microbial protein targets: towards understanding and intervention

Paul W. Denny

Published November 16, 2017