Profile

Dr. Pradip Sen

Role

Principal Scientist

Speciality

Leishmania donovani

University/Institution

CSIR-Institute of Microbial Technology

Location

Chandigarh, India

Pradip Sen did his Ph.D. in immunobiology of visceral leishmaniasis with Dr. Syamal Roy from CSIR-Indian Institute of Chemical Biology (1994-2000), after which he went to Germany for post doctoral research in tumor immunology at Medical Faculty, Charite, Humboldt University. In 2001, Dr. Sen moved to University of North Carolina at Chapel Hill, USA, where he carried out another post doctoral research in Type-1 diabetes under Prof. Roland Tisch until he joined CSIR-Institute of Microbial Technology (CSIR-IMTECH) as Scientist in 2005. Since 2013, Dr. Pradip Sen is working as Principal Scientist at CSIR-IMTECH. Dr. Sen’s group has deciphered the mechanism by which antimony-resistant clinical isolates of Leishmania donovani attenuates the therapeutic efficacy of sodium antimony gluconate (SAG) by inhibiting dendritic cells, the key regulators of anti-leishmanial immune responses (PLoS Pathogens 6, e1000907, 2010). This was the first report that showed how host cells respond differentially to antimony-resistant and antimony-sensitive Leishmania parasites, which may influence the disease outcome. Currently, Dr. Sen’s group is exploring the role of a novel receptor in Leishmania donovani infection. In addition, Dr. Sen and his group are involved in developing monoclonal antibody-based biotherapeutics at CSIR-IMTECH.

3 publications that reflect my groups research efforts in the area of NTDs

  1. Arun Kumar Haldar, Vinod Yadav, Eshu Singhal, Kamlesh Kumar Bisht, Alpana Singh, Suniti Bhaumik, Rajatava Basu, Pradip Sen* and Syamal Roy (2010). Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. PLoS Pathogens. 6, e1000907. (*Single corresponding author).
  2. Jayati Mookerjee Basu, Ananda Mookerjee, Prosenjit Sen, Suniti Bhaumik, Pradip Sen, Subha Banerjee, Khudiram Naskar, Soumitra K. Choudhuri, Bhaskar Saha, Sanghamitra Raha and Syamal Roy (2006). Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via Phosphoinositide 3 Kinase and Mitogen-Activated Protein Kinase activation in Leishmania donovani-infected macrophages. Antimicrobial Agents and Chemotherapy. 50 (5): 1788-1797.
  3. Kaushik Roychoudhury, Biplab Dasgupta, Pradip Sen, Tamas Laskay, Werner Solbach, Tripti De and Syamal Roy (2006).  Evidence of direct interactions between the CC-chemokines CCL3, CCL4 and CCL5 and Leishmania promastigotes. Molecular and Biochemical Parasitology. 150 (2): 374-377.