Profile

Adriano Cappellazzo Coelho

Role

Assistant Professor

Speciality

Leishmania

University/Institution

Department of Animal Biology, Institute of Biology, State University of Campinas

Location

Campinas, Brazil

Assistant Professor, Department of Animal Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil (since 2016). My research is focused on the study of the molecular mechanisms of drug susceptibility and resistance in strains and clinical isolates of the parasitic protozoa of the genus Leishmania. I have experience in the investigation of drug activity in vitro and in vivo against leishmaniasis. I have been also working with the identification and characterization genes of the parasite, the molecular typing of Leishmania species, the generation of genetically modified parasites, among others. Recently, we have described the development and application of parasites expressing luciferase with the aim to facilitate the evaluation of drug efficacy in vitro and in animal models.

 

3 publications that reflect my groups research efforts in the area of NTDs:

1: Espada CR, Ribeiro-Dias F, Dorta ML, Pereira LIA, Carvalho EM, Machado PR, Schriefer A, Yokoyama-Yasunaka JKU, Coelho AC, Uliana SRB. Susceptibility to Miltefosine in Brazilian Clinical Isolates of Leishmania (Viannia) braziliensis. Am J Trop Med Hyg. 2017 Mar;96(3):656-659. doi: 10.4269/ajtmh.16-0811.

2: Coelho AC, Oliveira JC, Espada CR, Reimão JQ, Trinconi CT, Uliana SR. A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome. PLoS Negl Trop Dis. 2016 May 4;10(5):e0004660. doi: 10.1371/journal.pntd.0004660.

3: Coelho AC, Trinconi CT, Senra L, Yokoyama-Yasunaka JK, Uliana SR. Leishmania is not prone to develop resistance to tamoxifen. Int J Parasitol Drugs Drug Resist. 2015 Jun 17;5(3):77-83. doi: 10.1016/j.ijpddr.2015.05.006.